Differential expression of microRNA-206 in skeletal muscle of female Piedmontese and Friesian cattle.
نویسندگان
چکیده
The double-muscle phenotype is an inherited condition in Piedmontese cattle traced to a point mutation in the myostatin gene. To investigate the potential role of muscle-specific miRNAs in determining muscle development in cattle, this study examined the patterns of expression of microRNAs (miRNA-1) and miRNA-206 in Piedmontese and Friesian cattle according to phenotype and sex. There were no significant differences in miRNA-1 expression between different muscle phenotypes, sexes or breeds, whereas there was significantly higher expression of miRNA-206 in female Piedmontese compared with female Friesian cattle.
منابع مشابه
Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133.
The expression of three microRNAs, miR-1, miR-206 and miR-133 is restricted to skeletal myoblasts and cardiac tissue during embryo development and muscle cell differentiation, which suggests a regulation by muscle regulatory factors (MRFs). Here we show that inhibition of C2C12 muscle cell differentiation by FGFs, which interferes with the activity of MRFs, suppressed the expression of miR-1, m...
متن کاملThe Response of Skeletal Muscle-Expressed Neurotrophins to Acute Resistance Exercise in Male Wistar Rats
Background. BDNF and NT-4/5 have been proposed to be involved in the coordinated adaptations of the neuromuscular system to the elevated level of activity, but an activity-dependent expression of neurotrophins in skeletal muscle is not well established. Objectives. We, therefore, investigated the effect of one session of resistance exercise on mRNA expression of some neurotrophins in Slow and ...
متن کاملAltered Levels of MicroRNA-9, -206, and -132 in Spinal Muscular Atrophy and Their Response to Antisense Oligonucleotide Therapy
The identification of noninvasive biomarkers to monitor the disease progression in spinal muscular atrophy (SMA) is becoming increasingly important. MicroRNAs (miRNAs) regulate gene expression and are implicated in the pathogenesis of neuromuscular diseases, including motor neuron degeneration. In this study, we selectively characterized the expression of miR-9, miR-206, and miR-132 in spinal c...
متن کاملMutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.
A visibly distinct muscular hypertrophy (mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds. The autosomal recessive mh locus causing double-muscling condition in these cattle maps to bovine chromosome 2 within the same interval as myostatin, a member of the TGF-beta superfamily of genes. Because targeted disruption of myostatin ...
متن کاملThe effect of high-intensity interval training (HIIT) on gene expression of apoptotic markers in the skeletal muscle of diabetic rats
Background and Aims: Apoptosis plays important roles in the pathophysiology of Type 2 diabetes. The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) on gene expression of apoptotic markers in the skeletal muscle of diabetic rats. Methods: To implementation of this experimental research, 60 male Wistar rats weighing 220 ± 20 gr randomly were divided into 5 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Veterinary journal
دوره 190 3 شماره
صفحات -
تاریخ انتشار 2011